How do Proton Pump Inhibitors Work?
Proton pump inhibitors (PPIs) reduce the amount of acid made by your stomach. They are commonly used to treat acid reflux and ulcers of the stomach and part of the gut called the duodenum. Most people who take a PPI do not develop any side-effects.
Serious potential side effects or complications linked to proton pump inhibitors like Prilosec OTC, Prevacid and Nexium include: kidney disease, serious kidney complications, renal failure, and bone fracture. Individuals who use Nexium or Prilosec OTC daily for more than a year, particularly individuals who are 50 years old or older, may be at increased risk for hip fracture, wrist fracture, and/or spine fracture. Men and women that use Prilosec or Nexium appear to have a 20-50% increased risk for acquiring chronic kidney disease compared with individuals who do not.